Before you inject pegintron, the powder must be mixed with 0. Pegintron peginterferon alfa2b pharmacy coverage policy. Hold the vial and syringe and slowly turn the vial upside down with the needle still inside the vial. Compare intron a vs pegintron comprehensive analysis by treato. See the fda package insert see pregnancy safe medications. Peginterferon alfa2b pegintron treatment hepatitis c online.
Pegintron injection for surveillance is a weightbased dosing product administered at a dose of 0. The pdf file should be the first option within the insert dialog window. Open powerpoint and display the slide where you want to insert the pdf text. For hepatitis c it is typically used with ribavirin and cure rates are between 33 and 82%. The molecular weight of the peg portion of the molecule is 12,000 daltons. If youre creating a microsoft powerpoint presentation, you can insert a pdf document by following these steps. A clinically significant pharmacokinetic interaction was not observed between peginterferon alfa 2b pegintron and tolbutamide, midazolam or dapsone. Administration of treatment is not part of this study. Pegintron tm, peginterferon alfa2b, powder for injection, is a covalent conjugate of recombinant alfa interferon with monomethoxy polyethylene glycol peg. Pegintron peginterferon alfa2b injection, for subcutaneous use initial u. The interferon papers part iii inf and et, pv, and mf. In the insert object box, select create from file, and then enter the pdf file location. Taking peginterferon may result in the development of mood or behavioral problems, including depression, irritability, aggressive behavior, relapse into drug addiction or overdose if you are a former drug addict, and thoughts of suicide or hurting others. Compare prices, print coupons and get savings tips for pegintron and other hepatitis c drugs at cvs, walgreens, and other pharmacies.
Nipent pentostatin for injection is supplied as a sterile, apyrogenic, lyophilized powder in singledose vials for intravenous administration. Always talk with your doctor before you take any medication while pregnant. Patients transitioning from pegintron redipen to pegintron vial should receive appropriate instructions from a healthcare provider, as well as the medication guide and instructions for use for pegintron powder for injection, prior to first time use of pegintron vial. Hold the vial of peginterferon alfa2b upright without touching the cleaned top of the vial with your hands. Pegintron definition of pegintron by medical dictionary. The average molecular weight of the pegintron molecule is approximately 31,000 daltons. Work with the most accurate pdf to powerpoint converter. Keep your thumb pressed down on the dosing button for an additional 5 seconds to make sure that you get the complete dose. This emedtv web selection examines what causes hepatitis c and how this medicine may help fight the virus. It is not known if pegintron passes into your breast milk.
Pegintron information, side effects, warnings and recalls. Apr 09, 2020 before starting, collect all of the supplies that you will need to use for preparing and injecting pegintron. Peginterferon alfa2b pegintron treatment hepatitis c. If your healthcare provider also prescribes an approved hepatitis c. Peginterferon alfa2b is contraindicated in patients with known hypersensitivity reactions to alpha interferons, including peginterferon alfa2b or any of its components. Every year, thousands of americans are prescribed pegintron by their doctors to treat hepatitis c. For patients weighing greater than 105 kg greater than 231 pounds, the pegintron dose of 1. Specifically, we focus on the evolution of past, current, and future hcv treatment options, the reasons for treatment failure, and the impact of resistance. Follow these steps to use adobe acrobat to combine or merge word, excel, powerpoint, audio, or video files, web pages, or existing pdfs.
The volume of pegintron to be injected depends on the strength of pegintron and patients body weight s. Pegintron injection surveillance plan study p04123 full. Pegintron dosage for hepatitis c in adults for adults age 18 and older with genotype 1 infections, the recommended pegintron dose for treating hepatitis c is 1. Pegintron injection surveillance plan study p04123 the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Combine or merge files into a single pdf, adobe acrobat dc. They may include headache, feeling tired, mood changes. Press the dosing button down slowly and firmly until you can not push it any further. Side effect rates for pegintron peginterferon alfa2b 0 reports these are side effects of pegintron peginterferon alfa2b reported to the fda by people taking it, and by doctors and pharmacists. The quality of the pdf file is reduced with this method, but you can open the full pdf file by doubleclicking the image when viewing or editing in normal view. The decision to further extend the treatment period to one year for some patients should be based on prognostic factors such as age 40 years, male gender andor bridging fibrosis.
Pegasys is used for the treatment of hepatitis b and c whereas, pegintron is used for the treatment of melanoma and hepatitis c except for hepatitis b. Pegintron peginterferon alfa2b basics, side effects. Peginterferon alfa2a comes as a solution liquid in a vial, a prefilled syringe, and a disposable autoinjector to inject subcutaneously into the fatty layer just under the skin. Aug 28, 2019 pegintron redipen prefilled pen or vial strength to use amount of pegintron to administer mcg volume of pegintron to administer ml when reconstituted as directed. Before we begin, you should be aware of the two ways you can do this. Ophthalmologic disorders decrease or loss of vision, retinopathy including macular edema, retinal artery or vein thrombosis, retinal hemorrhages and cotton wool spots, optic neuritis, and papilledema may be induced or aggravated by treatment with pegintron alpha 2b or other alpha interferons.
It is ideal for presenting data contained within other. Insert pdf file content into a powerpoint presentation. These are side effects of pegintron peginterferon alfa2b reported to the fda by people taking it, and by doctors and pharmacists. If a serious adverse reaction develops during the course of treatment, discontinue or modify the dosage of pegintron and ribavirin until the adverse event abates or decreases in severity see warnings and precautions 5. The vial contains an excess amount of sterile water 5 ml. Pegintronrebetol should not be used in patients with creatinine clearance less than 50 mlmin. Each vial contains 10 mg of pentostatin and 50 mg of mannitol, usp. Pegylated interferon alfa2b, sold under the brand name pegintron among others, is a medication used to treat hepatitis c and melanoma. If your pdf is in a presentation format, the conversion should be no problem.
The decision to further extend the treatment period to one year for some patients should be based on prognostic factors such as age 40. A discussion of offlabel uses for pegintron is also provided. If you have chronic hepatitis c, your healthcare provider may prescribe pegintron. It is usually injected once a week, on the same day of the week, and at around the same time of day.
There is a risk of serious hypersensitivity reactions or anaphylaxis with peginterferon alfa2b, including angioedema, acute bronchospasm, urticaria, or other allergictype. All subjects were on stable methadone maintenance therapy receiving greater than or equal to 40 mgday prior to initiating pegintron. Insert the needle into the pinched skin at an angle of 45 to 90. Turn your pdf presentations to editable powerpoint ppt and pptx slideshows.
Difference between pegasys and pegintron compare the. If persistent or recurrent serious adverse events develop despite adequate dosage adjustment, discontinue treatment. Pegintron prefilled pen 120 mcg ministry of health. Click the image and it will be inserted into the slide. Pegintron monotherapy of chronic hepatitis c in previously untreated patients who have compensated liver disease and contraindications to or significant intolerances to ribavirin. See rebetol package insert for additional information and other warnings. Pegintron, pegasys, intron a, and sylatron prior authorization form if this is an urgent request, please call upmc health plan pharmacy services. Talk to your healthcare provider about the best way to feed your baby if you take pegintron. Combine files into a single pdf, insert a pdf into another pdf, insert a clipboard selection into a pdf, or place insert a pdf as a link in another file. These highlights do not include all the information needed to. Patient has a diagnosis of chronic hepatitis c with compensated liver disease and. With the other hand, slowly pull the plunger back to fill the syringe with the exact amount of pegintron into the syringe your healthcare provider told you to use. Interferon and the treatment of polycythemia vera, essential thrombocythemia and myelofibrosis the final word on interferon and mpn treatment comes from the three men who share the deepest clinical experience in applying a molecule derived from the cells own defenses to roll back the effects of myeloproliferative. Pegintron causes fewer mild side effects such as nausea, pain at the site of injection, fever and hair loss.
A pdf document is filled with all kinds of content, including text or images, that you might want to import elsewhere. When taking pegintron in combination with ribavirin, you should also read the ribavirin medication guide. Optical character recognition converts nonselectable text from scanned documents into editable office files. It is used to treat chronic hepatitis c infections. It works even better when combined with both ribavirin and a hepatitis c protease inhibitor like incivek or victrelis, although such a combination is. Medication guide pegintron peg intron peginterferon alfa2b for injection, for subcutaneous use important. For each injection you will need a pegintron vial package that contains. This is pegintron redipen by dcri on vimeo, the home for high quality videos and the people who love them. Tell your healthcare provider about all the medicines you take, including prescription and overthecounter medicines, vitamins, and herbal supplements.
Pegintron is the band name of peginterferon alfa 2b that is produced for treating skin cancers melanoma and hepatitis. These highlights do not include all the information needed. Pegintron injection surveillance plan study p04123. This is the key difference between pegasys and pegintron. Inserting a pdf as an image is a quick way to present flat data in a noninteractive fashion. Compare intron a vs pegintron comprehensive analysis by. Rebetol rebetol monotherapy is not effective for the treatment of chronic hepatitis c virus infection and should not be used alone for this indication. Pegintron redipen prefilled pen or vial strength to use amount of pegintron to administer mcg volume of pegintron to administer ml when reconstituted as directed. If your healthcare provider also prescribes an approved hepatitis c virus hcv medicine. Convert pdf to powerpoint convert your pdfs to powerpoint. Surveillance will be conducted after administration of peginterferon alfa2b administered according to the directions on the products labeling. Pegintron drug utilizes the jakstat signaling pathway as. Adjuvant treatment of melanoma with microscopic or gross nodal involvement within 84 days of definitive surgical resection including complete. Risk of serious disorders see full prescribing information for complete boxed warning.
Please refer to the ribavirin and boceprevir physicians insert when pegintron is to be used in combination with these medicines. Oct 29, 2017 pegintron is the band name of peginterferon alfa 2b that is produced for treating skin cancers and hepatitis. Listing a study does not mean it has been evaluated by the u. Description pegintron tm, peginterferon alfa2b, powder for injection, is a covalent conjugate of recombinant alfa interferon with monomethoxy polyethylene glycol peg.
Peginterferon alfa2b is a manmade drug that acts like a protein made by the body. Bitherapy and monotherapy pegintron is indicated for the treatment of adult patients 18 years of age and older with. The dose of peginterferon alfa2b may require modification due to development of laboratory abnormalities, such as leukopenia, anemia, or thrombocytopenia. The symptoms might develop into fatal conditions such as psychosis, thrombosis formation of blood clots and liver problems. Read the medication guide and instructions for use provided by your pharmacist before you start using peginterferon alfa2b and each time you get a refill.
Pegintron fda prescribing information, side effects and uses. Pegintron peginterferon alfa2b will be considered for coverage under the pharmacy benefit program when the following criteria are met. A patient should selfinject pegintron only if the physician determines that it is appropriate and the patient agrees to medical followup as necessary and has been trained in proper injection technique see. It is given by injection under the skin side effects are common. Apr 09, 2020 the pharmacokinetics of concomitant administration of methadone and pegintron were evaluated in 18 pegintronnaive chronic hepatitis c subjects receiving 1. The ph of the final product is maintained between 7. For additional questions, contact merck at 18004442080. Insert the syringe needle into the peginterferon alfa2b solution vial, and press down on the plunger to inject the air into the vial. The examination made before the treatment, during the treatment and after it included clinical, biochemical, virusological.
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